Mitotic WNT: aligning chromosomes through KIF2A

Abstract

WNT signaling regulates cell cycle progression and fate determination through β-catenin dependent transcription, and its misregulation is often associated with tumorigenesis. Our recent work demonstrated that basal WNT activity is also required to ensure proper chromosome alignment during mitosis through the regulation of kinesin family member 2A (KIF2A).

Keywords

• wnt signaling
• kinesin-13
• disheveled
• chromosome congression
• plk1