Nature Communications (Aug 2016)
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling
- Jaba Gamrekelashvili,
- Roberto Giagnorio,
- Jasmin Jussofie,
- Oliver Soehnlein,
- Johan Duchene,
- Carlos G. Briseño,
- Saravana K. Ramasamy,
- Kashyap Krishnasamy,
- Anne Limbourg,
- Christine Häger,
- Tamar Kapanadze,
- Chieko Ishifune,
- Rabea Hinkel,
- Freddy Radtke,
- Lothar J. Strobl,
- Ursula Zimber-Strobl,
- L. Christian Napp,
- Johann Bauersachs,
- Hermann Haller,
- Koji Yasutomo,
- Christian Kupatt,
- Kenneth M. Murphy,
- Ralf H. Adams,
- Christian Weber,
- Florian P. Limbourg
Affiliations
- Jaba Gamrekelashvili
- Department of Nephrology and Hypertension, Hannover Medical School
- Roberto Giagnorio
- Department of Nephrology and Hypertension, Hannover Medical School
- Jasmin Jussofie
- Department of Cardiology, Hannover Medical School
- Oliver Soehnlein
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
- Johan Duchene
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
- Carlos G. Briseño
- Department of Pathology and Immunology, Washington University in St Louis, School of Medicine
- Saravana K. Ramasamy
- Max Planck Institute for Molecular Biomedicine
- Kashyap Krishnasamy
- Department of Nephrology and Hypertension, Hannover Medical School
- Anne Limbourg
- Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School
- Christine Häger
- Department of Cardiology, Hannover Medical School
- Tamar Kapanadze
- Department of Nephrology and Hypertension, Hannover Medical School
- Chieko Ishifune
- Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University
- Rabea Hinkel
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
- Freddy Radtke
- Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, ISREC
- Lothar J. Strobl
- Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- Ursula Zimber-Strobl
- Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH)
- L. Christian Napp
- Department of Cardiology, Hannover Medical School
- Johann Bauersachs
- Department of Cardiology, Hannover Medical School
- Hermann Haller
- Department of Nephrology and Hypertension, Hannover Medical School
- Koji Yasutomo
- Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University
- Christian Kupatt
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
- Kenneth M. Murphy
- Department of Pathology and Immunology, Washington University in St Louis, School of Medicine
- Ralf H. Adams
- Max Planck Institute for Molecular Biomedicine
- Christian Weber
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
- Florian P. Limbourg
- Department of Nephrology and Hypertension, Hannover Medical School
- DOI
- https://doi.org/10.1038/ncomms12597
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Circulating Ly6Clo monocytes are thought to be derived from Ly6Chi subset. Here the authors show that Notch signalling is activated in Ly6Clocells and is required for their differentiation, and that Notch ligands that initiate this signalling are provided by a subset of endothelial cells.
