PLoS Biology (Sep 2023)

A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.

  • Christopher G Hubert,
  • Shaun R Stauffer,
  • Justin D Lathia

DOI
https://doi.org/10.1371/journal.pbio.3002295
Journal volume & issue
Vol. 21, no. 9
p. e3002295

Abstract

Read online

Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.