Nature Communications (Dec 2019)
The upper-airway microbiota and loss of asthma control among asthmatic children
- Yanjiao Zhou,
- Daniel Jackson,
- Leonard B. Bacharier,
- David Mauger,
- Homer Boushey,
- Mario Castro,
- Juliana Durack,
- Yvonne Huang,
- Robert F. Lemanske,
- Gregory A. Storch,
- George M. Weinstock,
- Kristine Wylie,
- Ronina Covar,
- Anne M. Fitzpatrick,
- Wanda Phipatanakul,
- Rachel G. Robison,
- Avraham Beigelman
Affiliations
- Yanjiao Zhou
- Department of Medicine, University of Connecticut
- Daniel Jackson
- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health
- Leonard B. Bacharier
- Department of Pediatrics, St. Louis Children’s Hospital, Washington University School of Medicine
- David Mauger
- Department of Public Health Sciences, Penn State University
- Homer Boushey
- Department of Medicine, University of California
- Mario Castro
- Department of Medicine, St. Louis Children’s Hospital, Washington University School of Medicine
- Juliana Durack
- Department of Medicine, University of California
- Yvonne Huang
- Department of Medicine, University of Michigan
- Robert F. Lemanske
- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health
- Gregory A. Storch
- Department of Pediatrics, St. Louis Children’s Hospital, Washington University School of Medicine
- George M. Weinstock
- The Jackson Laboratory for Genomic Medicine
- Kristine Wylie
- Department of Pediatrics, St. Louis Children’s Hospital, Washington University School of Medicine
- Ronina Covar
- National Jewish Health
- Anne M. Fitzpatrick
- Department of Pediatrics, Emory University
- Wanda Phipatanakul
- Asthma, Allergy and Immunology, Boston Children’s Hospital, Harvard Medical School
- Rachel G. Robison
- Ann and Robert H Lurie Children’s Hospital of Chicago
- Avraham Beigelman
- Department of Pediatrics, St. Louis Children’s Hospital, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-13698-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
How the airway microbiome influences asthma pathophysiology remains unclear. Here, the authors analyse nasal samples of cohort of school-age children with persistent asthma and find that the microbiota’s patterns and composition at time of early loss of asthma control associate with severe asthma exacerbations.
