Prognostic Relevance of Promoter Hypermethylation of Multiple Genes in Breast Cancer Patients

Gayatri Sharma; Sameer Mirza; Yi-Hsin Yang; Rajinder Parshad; Priya Hazrah; Siddartha Datta Gupta; Ranju Ralhan

doi:10.3233/CLO-2009-0507

Cellular Oncology (Jan 2009)

Prognostic Relevance of Promoter Hypermethylation of Multiple Genes in Breast Cancer Patients

Gayatri Sharma,
Sameer Mirza,
Yi-Hsin Yang,
Rajinder Parshad,
Priya Hazrah,
Siddartha Datta Gupta,
Ranju Ralhan

Affiliations

Gayatri Sharma: Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Sameer Mirza: Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Yi-Hsin Yang: Department of Oral Hygiene, Kaohsiung Medical University, Kaohsiung, Taiwan
Rajinder Parshad: Department of Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Priya Hazrah: Department of Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Siddartha Datta Gupta: Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Ranju Ralhan: Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

DOI: https://doi.org/10.3233/CLO-2009-0507
Journal volume & issue: Vol. 31, no. 6
pp. 487 – 500

Abstract

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Background: Methylation-mediated suppression of detoxification, DNA repair and tumor suppressor genes has been implicated in cancer development. This study was designed to investigate the impact of concurrent methylation of multiple genes in breast tumors on disease prognosis.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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