RECURRENT HYDATIDIFORM MOLE COMPLICATED BY TOXIC GOITRE

Abstract

Hyperthyroidism complicates few pregnancies, in many cases due to Graves' disease. Gestational trophoblastic disease is a rare cause of hyperthyroidism in which high levels of hCG causes activation of the thyrotrophin receptor to stimulate supraphysiological secretion of thyroid hormone with or without thyroid gland enlargement. Molar pregnancies are usually not recurrent, however, women with a previous hydatidiform mole (HM) are at higher risk of having a second mole than women from the general population. After a prior molar pregnancy, the risk of having a second one is 540 times that of the general population, however, familial molar pregnancies are exceedingly rare. Here we present a case of recurrent HM complicated by a toxic goiter in a patient with family history of molar pregnancy