Malaria Journal (Apr 2012)

A histopathologic study of fatal paediatric cerebral malaria caused by mixed <it>Plasmodium falciparum</it>/<it>Plasmodium vivax </it>infections

  • Manning Laurens,
  • Rosanas-Urgell Anna,
  • Laman Moses,
  • Edoni Henry,
  • McLean Catriona,
  • Mueller Ivo,
  • Siba Peter,
  • Davis Timothy ME

DOI
https://doi.org/10.1186/1475-2875-11-107
Journal volume & issue
Vol. 11, no. 1
p. 107

Abstract

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Abstract Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria. Severely-ill Papua New Guinean children with mixed P. falciparum/P. vivax infections are more likely to develop cerebral malaria and die than those with P. falciparum alone, possibly reflecting P. vivax sequestration. Nested PCR was performed on post mortem brain tissue from three such children dying from cerebral malaria due to mixed-species infections. No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain.

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