Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

Lu Chen; Lin Zhu; Di Lu; Zhe Wu; Yanbing Han; Puying Xu; Lvhua Chang; Qian Wu

doi:10.3389/fnmol.2020.554547

Frontiers in Molecular Neuroscience (Sep 2020)

Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

Lu Chen,
Lin Zhu,
Di Lu,
Zhe Wu,
Yanbing Han,
Puying Xu,
Lvhua Chang,
Qian Wu

Affiliations

Lu Chen: Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China
Lin Zhu: Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China
Di Lu: Biomedicine Engineering Research Centre, Kunming Medical University, Kunming, China
Zhe Wu: Department of Psychology, The First People’s Hospital of Yunnan Province, Kunming, China
Yanbing Han: Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China
Puying Xu: Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China
Lvhua Chang: Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China
Qian Wu: Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China

DOI: https://doi.org/10.3389/fnmol.2020.554547
Journal volume & issue: Vol. 13

Abstract

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Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central nervous system (CNS) that have been proven to be related to the pathogenesis and development of epilepsy. Additionally, interleukin 4 (IL-4) is an anti-inflammatory factor that can regulate microglia and astrocytes in many aspects. This review article focuses on the regulatory role of IL-4 in the pathological changes of glial cells related to epilepsy. We additionally propose that IL-4 may play a protective role in epileptogenesis and suggest that IL-4 may be a novel therapeutic target for the treatment of epilepsy.

Published in Frontiers in Molecular Neuroscience

ISSN: 1662-5099 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/molecular-neuroscience

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