Prostate Cancer (Jan 2013)
Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent
- Timothy R. Rebbeck,
- Susan S. Devesa,
- Bao-Li Chang,
- Clareann H. Bunker,
- Iona Cheng,
- Kathleen Cooney,
- Rosalind Eeles,
- Pedro Fernandez,
- Veda N. Giri,
- Serigne M. Gueye,
- Christopher A. Haiman,
- Brian E. Henderson,
- Chris F. Heyns,
- Jennifer J. Hu,
- Sue Ann Ingles,
- William Isaacs,
- Mohamed Jalloh,
- Esther M. John,
- Adam S. Kibel,
- LaCreis R. Kidd,
- Penelope Layne,
- Robin J. Leach,
- Christine Neslund-Dudas,
- Michael N. Okobia,
- Elaine A. Ostrander,
- Jong Y. Park,
- Alan L. Patrick,
- Catherine M. Phelan,
- Camille Ragin,
- Robin A. Roberts,
- Benjamin A. Rybicki,
- Janet L. Stanford,
- Sara Strom,
- Ian M. Thompson,
- John Witte,
- Jianfeng Xu,
- Edward Yeboah,
- Ann W. Hsing,
- Charnita M. Zeigler-Johnson
Affiliations
- Timothy R. Rebbeck
- Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
- Susan S. Devesa
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
- Bao-Li Chang
- Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
- Clareann H. Bunker
- Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
- Iona Cheng
- Cancer Prevention Institute of California, Fremont, CA 94538, USA
- Kathleen Cooney
- Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
- Rosalind Eeles
- The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK
- Pedro Fernandez
- Stellenbosch University and Tygerberg Hospital, Cape Town 7505, South Africa
- Veda N. Giri
- Fox Chase Cancer Center, Philadelphia, PA 19111, USA
- Serigne M. Gueye
- Hôpital Général de Grand Yoff, Université Cheikh Anta Diop de Dakar, Dakar, Senegal
- Christopher A. Haiman
- Department of Preventive Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
- Brian E. Henderson
- Department of Preventive Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
- Chris F. Heyns
- Stellenbosch University and Tygerberg Hospital, Cape Town 7505, South Africa
- Jennifer J. Hu
- School of Medicine and Sylvester Cancer Center, University of Miami Miller, Miami, FL 33442, USA
- Sue Ann Ingles
- Department of Preventive Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
- William Isaacs
- The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21287, USA
- Mohamed Jalloh
- Hôpital Général de Grand Yoff, Université Cheikh Anta Diop de Dakar, Dakar, Senegal
- Esther M. John
- Cancer Prevention Institute of California, Fremont, CA 94538, USA
- Adam S. Kibel
- Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02138, USA
- LaCreis R. Kidd
- Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA
- Penelope Layne
- Guyana Cancer Registry, Ministry of Health, Queenstown, Guyana
- Robin J. Leach
- Department of Urology and the Cancer, Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, San Antonio, TX 78229, USA
- Christine Neslund-Dudas
- Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA
- Michael N. Okobia
- Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
- Elaine A. Ostrander
- National Human Genome Research Institute, Bethesda, MD 20892, USA
- Jong Y. Park
- Department of Cancer Epidemiology and Center for Equal Health, Moffitt Cancer Center, Tampa, FL 33612, USA
- Alan L. Patrick
- Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago
- Catherine M. Phelan
- Department of Cancer Epidemiology and Center for Equal Health, Moffitt Cancer Center, Tampa, FL 33612, USA
- Camille Ragin
- Fox Chase Cancer Center, Philadelphia, PA 19111, USA
- Robin A. Roberts
- School of Clinical Medicine and Research, University of the West Indies, Nassau, Bahamas
- Benjamin A. Rybicki
- Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA
- Janet L. Stanford
- Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Sara Strom
- Department of Epidemiology, MD Anderson Cancer Center, Houston, TX 77030, USA
- Ian M. Thompson
- Department of Urology and the Cancer, Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, San Antonio, TX 78229, USA
- John Witte
- Departments of Epidemiology and Biostatistics and Urology, Institute for Human Genetics, University of California, San Francisco, CA 94122, USA
- Jianfeng Xu
- Wake Forest University, Winston-Salem, NC 27157, USA
- Edward Yeboah
- Korle Bu Teaching Hospital and University of Ghana Medical School, Accra, Ghana
- Ann W. Hsing
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
- Charnita M. Zeigler-Johnson
- Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
- DOI
- https://doi.org/10.1155/2013/560857
- Journal volume & issue
-
Vol. 2013
Abstract
Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.
