The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

Maria-Cristina Keightley; Duncan P. Carradice; Judith E. Layton; Luke Pase; Julien Y. Bertrand; Johannes G. Wittig; Aleksandar Dakic; Andrew P. Badrock; Nicholas J. Cole; David Traver; Stephen L. Nutt; Julia McCoey; Ashley M. Buckle; Joan K. Heath; Graham J. Lieschke

doi:10.1038/ncomms14911

Nature Communications (Apr 2017)

The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

Maria-Cristina Keightley,
Duncan P. Carradice,
Judith E. Layton,
Luke Pase,
Julien Y. Bertrand,
Johannes G. Wittig,
Aleksandar Dakic,
Andrew P. Badrock,
Nicholas J. Cole,
David Traver,
Stephen L. Nutt,
Julia McCoey,
Ashley M. Buckle,
Joan K. Heath,
Graham J. Lieschke

Affiliations

Maria-Cristina Keightley: Australian Regenerative Medicine Institute, Monash University
Duncan P. Carradice: The Walter and Eliza Hall Institute of Medical Research
Judith E. Layton: The Walter and Eliza Hall Institute of Medical Research
Luke Pase: Australian Regenerative Medicine Institute, Monash University
Julien Y. Bertrand: Department of Pathology and Immunology, University of Geneva—CMU
Johannes G. Wittig: Australian Regenerative Medicine Institute, Monash University
Aleksandar Dakic: The Walter and Eliza Hall Institute of Medical Research
Andrew P. Badrock: Faculty of Life Sciences, The University of Manchester
Nicholas J. Cole: Motor Neuron Disease Research Group, Faculty of Medicine and Health Sciences, Macquarie University
David Traver: Department of Cellular and Molecular Medicine, University of California at San Diego
Stephen L. Nutt: The Walter and Eliza Hall Institute of Medical Research
Julia McCoey: Department of Biochemistry and Molecular Biology, Monash University
Ashley M. Buckle: Department of Biochemistry and Molecular Biology, Monash University
Joan K. Heath: The Walter and Eliza Hall Institute of Medical Research
Graham J. Lieschke: Australian Regenerative Medicine Institute, Monash University

DOI: https://doi.org/10.1038/ncomms14911
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Neutrophils are increased in response to injury and infection but how they form from a common granulocyte-macrophage progenitor is unclear. Here, the authors identify a role for the transcriptional repressor ZBTB11 in zebrafish, which is regulated by master myeloid regulators and repressesTP53.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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