Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

Yoel A. Klug; Justin C. Deme; Robin A. Corey; Mike F. Renne; Phillip J. Stansfeld; Susan M. Lea; Pedro Carvalho

doi:10.1038/s41467-021-26162-6

Nature Communications (Oct 2021)

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

Yoel A. Klug,
Justin C. Deme,
Robin A. Corey,
Mike F. Renne,
Phillip J. Stansfeld,
Susan M. Lea,
Pedro Carvalho

Affiliations

Yoel A. Klug: Sir William Dunn School of Pathology, University of Oxford
Justin C. Deme: Sir William Dunn School of Pathology, University of Oxford
Robin A. Corey: Department of Biochemistry, University of Oxford
Mike F. Renne: Sir William Dunn School of Pathology, University of Oxford
Phillip J. Stansfeld: Department of Biochemistry, University of Oxford
Susan M. Lea: Sir William Dunn School of Pathology, University of Oxford
Pedro Carvalho: Sir William Dunn School of Pathology, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-26162-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation by the yeast Seipin Sei1 and its partner Ldb16.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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