A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia

Masahiko Fukatsu; Hiroshi Ohkawara; Hiroshi Takahashi; Hirotaka Mori; Mai Yaginuma; Mamiko Endo; Akiko Shichishima-Nakamura; Takahiro Sano; Kayo Harada-Shirado; Satoshi Kimura; Kazuei Ogawa; Yuko Hashimoto; Takayuki Ikezoe

doi:10.1159/000517439

Case Reports in Oncology (Jul 2021)

A Case of Acquired von Willebrand Syndrome Complicated by Acute Myelomonocytic Leukemia

Masahiko Fukatsu,
Hiroshi Ohkawara,
Hiroshi Takahashi,
Hirotaka Mori,
Mai Yaginuma,
Mamiko Endo,
Akiko Shichishima-Nakamura,
Takahiro Sano,
Kayo Harada-Shirado,
Satoshi Kimura,
Kazuei Ogawa,
Yuko Hashimoto,
Takayuki Ikezoe

Affiliations

Masahiko Fukatsu: ORCiD; Department of Hematology, Fukushima Medical University, Fukushima, Japan
Hiroshi Ohkawara: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Hiroshi Takahashi: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Hirotaka Mori: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Mai Yaginuma: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Mamiko Endo: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Akiko Shichishima-Nakamura: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Takahiro Sano: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Kayo Harada-Shirado: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Satoshi Kimura: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Kazuei Ogawa: Department of Hematology, Fukushima Medical University, Fukushima, Japan
Yuko Hashimoto: Department of Diagnostic Pathology, Fukushima Medical University, Fukushima, Japan
Takayuki Ikezoe: Department of Hematology, Fukushima Medical University, Fukushima, Japan

DOI: https://doi.org/10.1159/000517439
Journal volume & issue: Vol. 14, no. 2
pp. 1152 – 1158

Abstract

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We here report a 21-year-old male who presented with acute myelomonocytic leukemia (AMML) associated with acquired von Willebrand syndrome (AVWS). To our knowledge, this is the first case of AVWS caused by AMML. In our case, following remission-induction chemotherapy combined with idarubicin and cytarabine, the patient showed remarkable improvement of bleeding symptoms due to AVWS. Moreover, after an allogeneic stem cell transplantation from a sibling donor, both AMML and AVWS maintain complete remission.

Published in Case Reports in Oncology

ISSN: 1662-6575 (Online)
Publisher: Karger Publishers
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.karger.com/cro

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