Research Progress of Hydrogen on Chronic Nasal Inflammation

Abstract

Ling Jin,1,2,* Shiwang Tan,1,* Kai Fan,1,* Yang Wang,1 Shaoqing Yu1,2 1Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Department of Allergy, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaoqing Yu, Department of Otolaryngology, Tongji Hospital, 389 Xincun Road, Putuo District, Shanghai, 200065, People’s Republic of China, Email [email protected]: Chronic nasal mucosal inflammatory disease is a common nasal disease, which is involved by inflammatory cells and a variety of cytokines. Its main pathological features are inflammatory reaction, increased secretion, mucosal swelling and thickening of nasal cavity or paranasal sinuses.It mainly includes chronic rhinitis (divided into allergic rhinitis, non-allergic rhinitis), chronic sinusitis (divided into with nasal polyps, without nasal polyps type), etc.The main symptoms of chronic rhinitis are nasal itching, sneezing, runny nose, and nasal congestion. The main symptoms of chronic sinusitis are nasal congestion, purulent or sticky nasal discharge, headache, and reduced sense of smell. They are a type of disease with a high incidence rate and seriously affect the quality of human life.Although the etiology and treatment of this type of disease have been extensively studied, there are still many aspects that are unclear.Currently, oxidative stress is believed to be an important link in the pathogenesis of chronic inflammatory diseases of the nasal mucosa. Therefore, anti-oxidative stress is a direction of research for the treatment of chronic nasal mucosal inflammatory diseases.Hydrogen, as a medically therapeutic gas, has been extensively studied for its antioxidant, anti-inflammatory, and anti-damage properties, and has been used in the treatment of various diseases.Although there are relatively few studies on the use of hydrogen for nasal inflammation, its positive effects have also been found. This article systematically summarizes the relevant research on the use of hydrogen to improve chronic nasal mucosal inflammation, with the aim of clarifying the ideas and indicating the direction for further research in the future.Keywords: hydrogen, chronic rhinitis, chronic sinusitis, allergic rhinitis, non-allergic rhinitis, research progress

Keywords

• hydrogen；chronic rhinitis；chronic sinusitis；allergic rhinitis；non-allergic rhinitis；research progress