Frontiers in Cell and Developmental Biology (Sep 2021)
Lipid Metabolism Was Associated With Oocyte in vitro Maturation in Women With Polycystic Ovarian Syndrome Undergoing Unstimulated Natural Cycle
- Tao Liu,
- Tao Liu,
- Tao Liu,
- Tao Liu,
- Tao Liu,
- Dongming Liu,
- Dongming Liu,
- Dongming Liu,
- Dongming Liu,
- Dongming Liu,
- Xueling Song,
- Xueling Song,
- Xueling Song,
- Xueling Song,
- Xueling Song,
- Jiangxue Qu,
- Jiangxue Qu,
- Jiangxue Qu,
- Jiangxue Qu,
- Jiangxue Qu,
- Xiaoying Zheng,
- Xiaoying Zheng,
- Xiaoying Zheng,
- Xiaoying Zheng,
- Xiaoying Zheng,
- Jia Li,
- Jia Li,
- Jia Li,
- Jia Li,
- Jia Li,
- Rui Yang,
- Rui Yang,
- Rui Yang,
- Rui Yang,
- Rui Yang,
- Shuo Yang,
- Shuo Yang,
- Shuo Yang,
- Shuo Yang,
- Shuo Yang,
- Xi Zhang,
- Xi Zhang,
- Xi Zhang,
- Xi Zhang,
- Xi Zhang,
- Haiyan Wang,
- Haiyan Wang,
- Haiyan Wang,
- Haiyan Wang,
- Haiyan Wang,
- Liying Yan,
- Liying Yan,
- Liying Yan,
- Liying Yan,
- Liying Yan,
- Caihong Ma,
- Caihong Ma,
- Caihong Ma,
- Caihong Ma,
- Caihong Ma,
- Rong Li,
- Rong Li,
- Rong Li,
- Rong Li,
- Rong Li,
- Jie Yan,
- Jie Yan,
- Jie Yan,
- Jie Yan,
- Jie Yan,
- Jie Qiao,
- Jie Qiao,
- Jie Qiao,
- Jie Qiao,
- Jie Qiao
Affiliations
- Tao Liu
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Tao Liu
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Tao Liu
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Tao Liu
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Tao Liu
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Dongming Liu
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Dongming Liu
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Dongming Liu
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Dongming Liu
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Dongming Liu
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Xueling Song
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Xueling Song
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Xueling Song
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Xueling Song
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Xueling Song
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Jiangxue Qu
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Jiangxue Qu
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Jiangxue Qu
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Jiangxue Qu
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Jiangxue Qu
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Xiaoying Zheng
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Xiaoying Zheng
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Xiaoying Zheng
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Xiaoying Zheng
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Xiaoying Zheng
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Jia Li
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Jia Li
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Jia Li
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Jia Li
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Jia Li
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Rui Yang
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Rui Yang
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Rui Yang
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Rui Yang
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Rui Yang
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Shuo Yang
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Shuo Yang
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Shuo Yang
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Shuo Yang
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Shuo Yang
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Xi Zhang
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Xi Zhang
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Xi Zhang
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Xi Zhang
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Xi Zhang
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Haiyan Wang
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Haiyan Wang
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Haiyan Wang
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Haiyan Wang
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Haiyan Wang
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Liying Yan
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Liying Yan
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Liying Yan
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Liying Yan
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Liying Yan
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Caihong Ma
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Caihong Ma
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Caihong Ma
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Caihong Ma
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Caihong Ma
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Rong Li
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Rong Li
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Rong Li
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Rong Li
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Rong Li
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Jie Yan
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Jie Yan
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Jie Yan
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Jie Yan
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Jie Yan
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Jie Qiao
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Jie Qiao
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Jie Qiao
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Jie Qiao
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Jie Qiao
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- DOI
- https://doi.org/10.3389/fcell.2021.719173
- Journal volume & issue
-
Vol. 9
Abstract
ObjectiveHyperlipidemia are common polycystic ovarian syndrome (PCOS)-related metabolic dysfunctions and can adversely affect assisted reproductive technology (ART) outcomes in controlled ovarian hyperstimulation (COH) cycles. The objective of this study is to analyze the relationship between lipid metabolism and ART outcomes in unstimulated natural cycles without the utilization of ovarian induction drugs, which is still uncertain.MethodsThis retrospective study included infertile women with PCOS between 21 and 40 years old undergoing unstimulated natural cycles from January 01, 2006 to December 31, 2019. Lipid metabolism was measured by body mass index (BMI) and serum biochemical parameters including total cholesterol (TC), triglycerides (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C). ART outcomes were measured by number of oocytes retrieved, oocyte maturation quality and developmental potential, clinical pregnancy and live birth.ResultsA total of 586 patients were included in this study. Multivariate Poisson log-linear analysis showed that high TC (≥5.18 mmol/L), triglycerides (TG) (≥1.76 mmol/L), LDL-C (≥3.37 mmol/L) levelsand low HDL-C levels (≤1.04 mmol/L) were significantly (PTC = 0.001, PTG < 0.001, PHDL–C < 0.001, PLDL–C < 0.001) associated with increased number of oocytes retrieved. BMI was significantly negatively associated with maturation rate (P < 0.001), fertilization rate (P < 0.001) and transferrable embryo rate (P = 0.002). High TG levels and low HDL-C levels were also associated with decreased maturation rate (PTG < 0.001, PHDL–C = 0.026). Logistic regression analysis showed statistically significant association between obesity (≥28.0 kg/m2) and decreased live birth rate (P = 0.004) as well as cumulative live birth rate (P = 0.007).ConclusionThis is the first study that focused on the relationship between basal lipid metabolism and ART outcomes in women with PCOS undergoing unstimulated natural cycles. The results showed that high levels of lipid metabolic parameters were associated with increased number of oocytes retrieved and obesity was closely associated with impaired oocyte maturation quality and developmental potential as well as poor live birth outcomes.
Keywords
- unstimulated natural cycle
- lipid metabolism
- number of oocyte retrieved
- oocyte quality
- clinical outcomes
- polycystic ovarian syndrome