Two new Cd(II)/Co(II) compounds: Luminescent and photocatalytic property, and treatment activity on coronary artery atherosclerosis

Abstract

Two new compounds, namely [Cd2(L)2(4-pybim)2(H2O)]n·3n(H2O) (1) and [Co(cam)(4-pybim)]n·n(H2O) (2) (H2L = succinic acid, H2cam = D-(+)-camphoric acid, 4-pybim = (4-pyridyl)benzimidazole), were successfully synthesized by the combination of carboxylate ligand, 4-pybim ligand and corresponding metal salts. Moreover, the luminescent property of 1 and photocatalytic activity of 2 were also investigated in detail. The application values of the new compounds against coronary artery atherosclerosis were evaluated and the detail mechanism was assessed simultaneously. First of all, the inflammatory cytokines levels released into plasma after compound treatment was measured with the detection of enzyme-linked immunosorbent assay. Then, the relative expression of the signaling pathway of NF-κb in the vascular endothelial cells was tested through exploiting the real time reverse transcription-polymerase.

Keywords

• Luminescence
• Photocatalysis
• Coronary artery atherosclerosis