Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis

Xianwei Wang; Hui Peng; Jingjing Cong; Xuefu Wang; Zhexiong Lian; Haiming Wei; Rui Sun; Zhigang Tian

doi:10.1038/s41467-018-07405-5

Nature Communications (Nov 2018)

Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis

Xianwei Wang,
Hui Peng,
Jingjing Cong,
Xuefu Wang,
Zhexiong Lian,
Haiming Wei,
Rui Sun,
Zhigang Tian

Affiliations

Xianwei Wang: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Hui Peng: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Jingjing Cong: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Xuefu Wang: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Zhexiong Lian: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Haiming Wei: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Rui Sun: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Zhigang Tian: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-018-07405-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Natural killer cells may respond better on second antigen encounters, but how this memory is induced or maintained in vivo is not clear. Here the authors show that memory NK cells expressing interleukin-7 (IL-7) receptor are induced in the lymph nodes but later recruited to liver for long term, IL-7 dependent survival and memory maintenance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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