Química Nova (Jan 2012)

Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist)

  • Rita de Cássia Saraiva Nunomura,
  • Angelo C. Pinto,
  • Sergio Massayoshi Nunomura,
  • Adrian Martin Pohlit,
  • Ana Cláudia Fernandes Amaral

DOI
https://doi.org/10.1590/S0100-40422012001100009
Journal volume & issue
Vol. 35, no. 11
pp. 2153 – 2158

Abstract

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Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene oxide, also isolated for the first time from this species and a new alkaloid (6-methoxy-(9H-β-carbolin-1-il)-(Z)-2-propenoic acid). Quantification of 9-methoxycanthin-6-one in different extracts and fractions of stems of S. guianensis by high performance liquid chromatography was also performed. The concentration of 9-methoxycanthin-6-one in methanolic and aqueous extracts were inferior to the known cytotoxic concentration of this compound.

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