Nature Communications (Oct 2021)
Clonal hematopoiesis is associated with risk of severe Covid-19
- Kelly L. Bolton,
- Youngil Koh,
- Michael B. Foote,
- Hogune Im,
- Justin Jee,
- Choong Hyun Sun,
- Anton Safonov,
- Ryan Ptashkin,
- Joon Ho Moon,
- Ji Yeon Lee,
- Jongtak Jung,
- Chang Kyung Kang,
- Kyoung-Ho Song,
- Pyoeng Gyun Choe,
- Wan Beom Park,
- Hong Bin Kim,
- Myoung-don Oh,
- Han Song,
- Sugyeong Kim,
- Minal Patel,
- Andriy Derkach,
- Erika Gedvilaite,
- Kaitlyn A. Tkachuk,
- Brian J. Wiley,
- Ireaneus C. Chan,
- Lior Z. Braunstein,
- Teng Gao,
- Elli Papaemmanuil,
- N. Esther Babady,
- Melissa S. Pessin,
- Mini Kamboj,
- Luis A. Diaz,
- Marc Ladanyi,
- Michael J. Rauh,
- Pradeep Natarajan,
- Mitchell J. Machiela,
- Philip Awadalla,
- Vijai Joseph,
- Kenneth Offit,
- Larry Norton,
- Michael F. Berger,
- Ross L. Levine,
- Eu Suk Kim,
- Nam Joong Kim,
- Ahmet Zehir
Affiliations
- Kelly L. Bolton
- Department of Medicine, Washington University
- Youngil Koh
- Department of Internal Medicine, Seoul National University Hospital
- Michael B. Foote
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Hogune Im
- Genome Opinion Inc.
- Justin Jee
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Choong Hyun Sun
- Genome Opinion Inc.
- Anton Safonov
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Ryan Ptashkin
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Joon Ho Moon
- Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University
- Ji Yeon Lee
- Department of Internal Medicine, National Medical Center
- Jongtak Jung
- Department of Internal Medicine, Seoul National University Bundang Hospital
- Chang Kyung Kang
- Department of Internal Medicine, Seoul National University Hospital
- Kyoung-Ho Song
- Department of Internal Medicine, Seoul National University Bundang Hospital
- Pyoeng Gyun Choe
- Department of Internal Medicine, Seoul National University Hospital
- Wan Beom Park
- Department of Internal Medicine, Seoul National University Hospital
- Hong Bin Kim
- Department of Internal Medicine, Seoul National University Bundang Hospital
- Myoung-don Oh
- Department of Internal Medicine, Seoul National University Hospital
- Han Song
- Genome Opinion Inc.
- Sugyeong Kim
- Genome Opinion Inc.
- Minal Patel
- Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center
- Andriy Derkach
- Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center
- Erika Gedvilaite
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Kaitlyn A. Tkachuk
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Brian J. Wiley
- Department of Medicine, Washington University
- Ireaneus C. Chan
- Department of Medicine, Washington University
- Lior Z. Braunstein
- Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center
- Teng Gao
- Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer Center
- Elli Papaemmanuil
- Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer Center
- N. Esther Babady
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Melissa S. Pessin
- Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Mini Kamboj
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Luis A. Diaz
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Marc Ladanyi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Michael J. Rauh
- Department of Pathology and Molecular Medicine, Queen’s University
- Pradeep Natarajan
- Cardiovascular Research Center, Massachusetts General Hospital
- Mitchell J. Machiela
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Philip Awadalla
- Ontario Institute for Cancer Research
- Vijai Joseph
- Clinical Genetics Research Lab, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Kenneth Offit
- Clinical Genetics Research Lab, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Larry Norton
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Michael F. Berger
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ross L. Levine
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Eu Suk Kim
- Department of Internal Medicine, Seoul National University Bundang Hospital
- Nam Joong Kim
- Department of Internal Medicine, Seoul National University Hospital
- Ahmet Zehir
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-26138-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Clonal haematopoiesis (CH) has been associated with altered inflammatory profiles and increased risk of cardiovascular and malignant diseases. Here, the authors analyze patient data from two different cohorts and show that CH is associated with severe infections and severe Covid19.
