Nature Communications (Feb 2016)
MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
- Duk-Hwa Kwon,
- Gwang Hyeon Eom,
- Jeong Hyeon Ko,
- Sera Shin,
- Hosouk Joung,
- Nakwon Choe,
- Yoon Seok Nam,
- Hyun-Ki Min,
- Taewon Kook,
- Somy Yoon,
- Wanseok Kang,
- Yong Sook Kim,
- Hyung Seok Kim,
- Hyuck Choi,
- Jeong-Tae Koh,
- Nacksung Kim,
- Youngkeun Ahn,
- Hyun-Jai Cho,
- In-Kyu Lee,
- Dong Ho Park,
- Kyoungho Suk,
- Sang Beom Seo,
- Erin R. Wissing,
- Susan M. Mendrysa,
- Kwang-Il Nam,
- Hyun Kook
Affiliations
- Duk-Hwa Kwon
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Gwang Hyeon Eom
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Jeong Hyeon Ko
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Sera Shin
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Hosouk Joung
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Nakwon Choe
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Yoon Seok Nam
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Hyun-Ki Min
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Taewon Kook
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Somy Yoon
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Wanseok Kang
- Department of Cardiology, Chonnam University Hospital
- Yong Sook Kim
- Department of Cardiology, Chonnam University Hospital
- Hyung Seok Kim
- Department of Forensic Medicine, Chonnam National University Medical School
- Hyuck Choi
- Department of Pharmacology and Dental Therapeutics, Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University
- Jeong-Tae Koh
- Department of Pharmacology and Dental Therapeutics, Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University
- Nacksung Kim
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- Youngkeun Ahn
- Department of Cardiology, Chonnam University Hospital
- Hyun-Jai Cho
- Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital
- In-Kyu Lee
- Department of Internal Medicine, Kyungpook National University School of Medicine
- Dong Ho Park
- Department of Ophthalmology, Kyungpook National University School of Medicine
- Kyoungho Suk
- Department of Pharmacology, Brain Science & Engineering Institute, Kyungpook National University School of Medicine
- Sang Beom Seo
- Department of Life Science, Chung-Ang University
- Erin R. Wissing
- Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University
- Susan M. Mendrysa
- Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University
- Kwang-Il Nam
- Departments of Anatomy, Chonnam National University Medical School
- Hyun Kook
- Department of Pharmacology and Medical Research Center for Gene Regulation, Chonnam National University Medical School
- DOI
- https://doi.org/10.1038/ncomms10492
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible therapeutic strategy for treatment of VC patients.
