Nature Communications (Jul 2018)
Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
- Philip Webster,
- Joanna C. Dawes,
- Hamlata Dewchand,
- Katalin Takacs,
- Barbara Iadarola,
- Bruce J. Bolt,
- Juan J. Caceres,
- Jakub Kaczor,
- Gopuraja Dharmalingam,
- Marian Dore,
- Laurence Game,
- Thomas Adejumo,
- James Elliott,
- Kikkeri Naresh,
- Mohammad Karimi,
- Katerina Rekopoulou,
- Ge Tan,
- Alberto Paccanaro,
- Anthony G. Uren
Affiliations
- Philip Webster
- MRC London Institute of Medical Sciences (LMS)
- Joanna C. Dawes
- MRC London Institute of Medical Sciences (LMS)
- Hamlata Dewchand
- MRC London Institute of Medical Sciences (LMS)
- Katalin Takacs
- MRC London Institute of Medical Sciences (LMS)
- Barbara Iadarola
- MRC London Institute of Medical Sciences (LMS)
- Bruce J. Bolt
- MRC London Institute of Medical Sciences (LMS)
- Juan J. Caceres
- Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London
- Jakub Kaczor
- MRC London Institute of Medical Sciences (LMS)
- Gopuraja Dharmalingam
- MRC London Institute of Medical Sciences (LMS)
- Marian Dore
- MRC London Institute of Medical Sciences (LMS)
- Laurence Game
- MRC London Institute of Medical Sciences (LMS)
- Thomas Adejumo
- MRC London Institute of Medical Sciences (LMS)
- James Elliott
- MRC London Institute of Medical Sciences (LMS)
- Kikkeri Naresh
- Imperial College Healthcare NHS Trust
- Mohammad Karimi
- MRC London Institute of Medical Sciences (LMS)
- Katerina Rekopoulou
- MRC London Institute of Medical Sciences (LMS)
- Ge Tan
- MRC London Institute of Medical Sciences (LMS)
- Alberto Paccanaro
- Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London
- Anthony G. Uren
- MRC London Institute of Medical Sciences (LMS)
- DOI
- https://doi.org/10.1038/s41467-018-05069-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting cancer gene loci, including negatively selected mutations.
