The Mutual Interplay between Bone, Glucose and Lipid Metabolism: The Role of Vitamin D and PTH

Vittoria Carmela Danese; Jessica Pepe; Federica Ferrone; Luciano Colangelo; Viviana De Martino; Luciano Nieddu; Giancarlo Ferrazza; Enrico Panzini; Roberto Pascone; Frank Blocki; Salvatore Minisola; Cristiana Cipriani

doi:10.3390/nu15132998

Nutrients (Jun 2023)

The Mutual Interplay between Bone, Glucose and Lipid Metabolism: The Role of Vitamin D and PTH

Vittoria Carmela Danese,
Jessica Pepe,
Federica Ferrone,
Luciano Colangelo,
Viviana De Martino,
Luciano Nieddu,
Giancarlo Ferrazza,
Enrico Panzini,
Roberto Pascone,
Frank Blocki,
Salvatore Minisola,
Cristiana Cipriani

Affiliations

Vittoria Carmela Danese: Department of Clinical, Internal Medicine, Cardiovascular and Anesthesiological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Jessica Pepe: Department of Clinical, Internal Medicine, Cardiovascular and Anesthesiological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Federica Ferrone: Department of Clinical, Internal Medicine, Cardiovascular and Anesthesiological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Luciano Colangelo: Department of Clinical, Internal Medicine, Cardiovascular and Anesthesiological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Viviana De Martino: Department of Clinical, Internal Medicine, Cardiovascular and Anesthesiological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Luciano Nieddu: Faculty of Economics, Università degli Studi Internazionali di Roma, Via Cristoforo Colombo 200, 00147 Rome, Italy
Giancarlo Ferrazza: Department of Immunohematology and Transfusion Medicine, Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Enrico Panzini: Department of Immunohematology and Transfusion Medicine, Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Roberto Pascone: Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
Frank Blocki: DiaSorin Inc., 1951 Northwestern Avenue, Stillwater, MN 55082, USA
Salvatore Minisola: Department of Clinical, Internal Medicine, Cardiovascular and Anesthesiological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Cristiana Cipriani: Department of Clinical, Internal Medicine, Cardiovascular and Anesthesiological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy

DOI: https://doi.org/10.3390/nu15132998
Journal volume & issue: Vol. 15, no. 13
p. 2998

Abstract

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Background. We sought to investigate the mutual interplay between bone, glucose and lipid metabolism in a wide cohort of community-based subjects. Methods. We studied 1240 blood donors (F/M ratio 1/3.2, mean age 41.9 ± 11.7 SD). Serum ionized (Ca++), magnesium (Mg++), 25-hydroxy-vitamin D [25(OH)D], PTH-1-84, 1,25-dihydroxyvitamin D [1,25(OH)2D], total cholesterol (C), HDL-C, triglycerides and glucose were measured and LDL-C levels were calculated in all subjects. Results. 25(OH)D negatively correlated with BMI (R = −0.11), PTH (R = −0.16) (p p p 2D (R = 0.12) and creatinine (R = 0.17) (p p p p p p p p p p = 0.05), while the odds of showing abnormal LDL-C levels increased in association with elevated PTH (p < 0.01). Conclusion. Vitamin D, PTH, glucose and lipid metabolism are mutually influenced. Hypovitaminosis D predisposes toward worsening lipid profiles through the actions of PTH, while serum PTH levels per se associate with higher glucose and LDL-C levels.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

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