Royan Institute First Attempts: Autotransplantation of Vitrified Human Ovarian Tissue in Cancer Patients
Naeimeh Sadat Abtahi,
Bita Ebrahimi,
Firouzeh Ghaffari,
Rohollah Fathi,
Mojtaba Rezazadeh Valojerdi,
Abolfazl Mehdizadeh Kashi,
Sepideh Khodaverdi,
Azar Yahyaei,
Maziar Faridi
Affiliations
Naeimeh Sadat Abtahi
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Bita Ebrahimi
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Firouzeh Ghaffari
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Rohollah Fathi
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Mojtaba Rezazadeh Valojerdi
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Abolfazl Mehdizadeh Kashi
Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
Sepideh Khodaverdi
Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
Azar Yahyaei
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Maziar Faridi
Department of Surgery, Iranmehr Hospital, Tehran, Iran
Today, timely diagnosis and therapeutic progress open a road of hope for survival in cancerous patients. Increasedknowledge about the various cytotoxic treatment's impacts on ovarian function and fertility has resulted in a surgein the number of patients seeking to preserve their fertility before starting the anti-cancer treatment process. In thisregard, embryo cryopreservation can be recommended for fertility preservation when the woman is married and hasadequate time for ovarian stimulation. If patients are prepubertal girls or not married women, oocytes or ovarian tissuecan be frozen instead to be used in the future. In this regard, the first attempts for ovarian tissue transplantations wereconducted in 2016 and in 2019 for two cancerous patients whose ovarian tissue was cryopreserved in the RoyanHuman Ovarian Tissue Bank (Tehran, Iran). Unfortunately, the transplantations did not result in a live birth.
