Efficacy and Tolerability of Levosulpiride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis

Abstract

Objective: This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to November 2013. Materials and Methods: The data collection was performed by the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), a question instrument for assessing the dyspeptic symptoms of functional dyspepsia in patients enrolled for the study. The symptoms were assessed at base line (Prior to initiation of therapy) and at 4 weeks, on a 5-point scale. Result: Among 120 patients 113 patients completed this study in three groups (G-1 Levosulpiride 40 patients, G-2 Domperidone 35 patients and G-3 Metoclopramide 38 patients) were followed up. Female gender dominated (75), occupation wise most of patients belonged to labour class (49). Highly significant improvement in symptoms scale was noticed in G-1 Levosulpiride 40 patients’ group. Conclusion: Functional Gastrointestinal disorders are not serious ailments but have a key impact on quality of life. Overall dyspeptic symptom relief rates were significantly high in the Levosulpiride group (p<0.004) as compared to Domperidone and Metoclopramide groups. A proper understanding of disease process by health care personnel and by sufferer is obligatory to enhance the quality of life and daunt the self/over the counter medication in this condition.

Keywords

• gastrointestinal disorders
• prokinetic
• quality of life