Scientific Reports (May 2022)
7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production
- Hao Dong,
- Chenjie Feng,
- Xiyunyi Cai,
- Yuanyuan Hao,
- Xinyue Gu,
- Lei Cai,
- Shuting Wu,
- Jiamin Chen,
- Zhou Liu,
- Wen Xie,
- Xuanren Lu,
- Hongfa Qian,
- Yulin Liu,
- Yiming Cao,
- Junlin Zhu,
- Jiayi Xu,
- Yanjie Zhou,
- Shuangyu Ma,
- Sha Yang,
- Yufeng Shi,
- Haojiang Yu,
- Minjie Shi,
- Yurong Wang,
- Harvest F. Gu,
- Lei Fan,
- Liang Wu
Affiliations
- Hao Dong
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Chenjie Feng
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Xiyunyi Cai
- School of Life Science and Technology, China Pharmaceutical University
- Yuanyuan Hao
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Xinyue Gu
- Department of Applied Mathematics and Statistics, The Johns Hopkins University
- Lei Cai
- School of Pharmacy, China Pharmaceutical University
- Shuting Wu
- School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Jiamin Chen
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Zhou Liu
- School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Wen Xie
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Xuanren Lu
- School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Hongfa Qian
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Yulin Liu
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Yiming Cao
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Junlin Zhu
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Jiayi Xu
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Yanjie Zhou
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Shuangyu Ma
- School of Traditional Chinese Pharmacy, China Pharmaceutical University
- Sha Yang
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Yufeng Shi
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Haojiang Yu
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Minjie Shi
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- Yurong Wang
- School of Basic Medicine and Clinical Pharmacy, Center for Pathophysiology, China Pharmaceutical University
- Harvest F. Gu
- School of Basic Medicine and Clinical Pharmacy, Center for Pathophysiology, China Pharmaceutical University
- Lei Fan
- Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Collaborative Innovation Center for Cancer Personalized Medicine
- Liang Wu
- Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University
- DOI
- https://doi.org/10.1038/s41598-022-12695-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Abstract 7-Met, a derivative of soybean isoflavone, is a natural flavonoid compound that has been reported to have multiple signaling pathways regulation effects. This study investigated the therapeutic effects of 7-Met on mice with atopic dermatitis induced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ). 7-Met ameliorated FITC or OXZ-induced atopic dermatitis symptoms by decreasing ear thickness, spleen index, mast cell activation, neutrophil infiltration and serum IgE levels in female BALB/c mice. In FITC-induced atopic dermatitis mice, 7-Met reduced Th1 cytokines production and regulated Th1/Th2 balance by downregulating the secretion of thymic stromal lymphopoietin (TSLP) via inactivation of the NF-κB pathway. In OXZ-induced atopic dermatitis, 7-Met functioned through the reduction of Th17 cytokine production. Our study showed that 7-Methoxyisoflavone alleviated atopic dermatitis by regulating multiple signaling pathways and downregulating chemokine production.
