Synthesis and Bioactivity of Luffarin I

Abstract

The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12–17 μM.

Keywords

• luffarin I
• sclareol
• diastereoselective reduction
• sponges
• sesterterpenolide
• marine metabolites