Journal of Animal Science and Biotechnology (Feb 2025)

The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs

  • Bei Zhou,
  • Junjie Guo,
  • Kan Xiao,
  • Yulan Liu

DOI
https://doi.org/10.1186/s40104-025-01165-1
Journal volume & issue
Vol. 16, no. 1
pp. 1 – 11

Abstract

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Abstract Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by iron overload and excessive lipid peroxidation. To date, numerous studies in human and mouse models have shown that ferroptosis is closely related to tissue damage and various diseases. In recent years, ferroptosis has also been found to play an indispensable and multifaceted role in infection and tissue injury in pigs, and nutritional regulation strategies targeting ferroptosis show great potential. In this review, we summarize the research progress of ferroptosis and its role in infection and tissue injury in pigs. Furthermore, we discuss the existing evidence on ferroptosis regulation by nutrients, aiming to provide valuable insights for future investigation into ferroptosis in pigs and offer a novel perspective for the treatment of infection and injury in pigs.

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