Adiponectinemia Is Associated with Uricemia but Not with Proinflammatory Status in Women with Metabolic Syndrome

Abstract

Metabolic syndrome (MS) is a cluster of glucose intolerance, hypertension, and dyslipidemia with visceral fat accumulation. This study was undertaken to assess which components of metabolic syndrome (MS), including uric acid and proinflammatory markers, are related to adiponectin levels in overweight and obese women with MS. Ninety-one women (60 with MS and 31 controls) were assessed in relation to classical and inflammatory parameters of MS. In comparison to controls, patients with MS showed significant differences in parameters that are typically associated with MS and in inflammatory markers. Fibrinogen, CRP, and C3 were positively, whereas albumin was inversely correlated with abdominal adiposity and insulin resistance. Adiponectin was inversely correlated with waist circumference and uric acid levels. Activities of adiponectin and proinflammatory markers are not correlated in overweight and obese women with MS. In addition to abdominal adiposity, uric acid may be implicated in a decrease of adiponectin in MS patients.