DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

Matthias S. Roost; Roderick C. Slieker; Monika Bialecka; Liesbeth van Iperen; Maria M. Gomes Fernandes; Nannan He; H. Eka D. Suchiman; Karoly Szuhai; Françoise Carlotti; Eelco J. P. de Koning; Christine L. Mummery; Bastiaan T. Heijmans; Susana M. Chuva de Sousa Lopes

doi:10.1038/s41467-017-01077-3

Nature Communications (Oct 2017)

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

Matthias S. Roost,
Roderick C. Slieker,
Monika Bialecka,
Liesbeth van Iperen,
Maria M. Gomes Fernandes,
Nannan He,
H. Eka D. Suchiman,
Karoly Szuhai,
Françoise Carlotti,
Eelco J. P. de Koning,
Christine L. Mummery,
Bastiaan T. Heijmans,
Susana M. Chuva de Sousa Lopes

Affiliations

Matthias S. Roost: Department of Anatomy and Embryology, Leiden University Medical Center
Roderick C. Slieker: Molecular Epidemiology Section, Leiden University Medical Center
Monika Bialecka: Department of Anatomy and Embryology, Leiden University Medical Center
Liesbeth van Iperen: Department of Anatomy and Embryology, Leiden University Medical Center
Maria M. Gomes Fernandes: Department of Anatomy and Embryology, Leiden University Medical Center
Nannan He: Department of Anatomy and Embryology, Leiden University Medical Center
H. Eka D. Suchiman: Molecular Epidemiology Section, Leiden University Medical Center
Karoly Szuhai: Department of Molecular Cell Biology, Leiden University Medical Center
Françoise Carlotti: Department of Nephrology, Leiden University Medical Center
Eelco J. P. de Koning: Department of Nephrology, Leiden University Medical Center
Christine L. Mummery: Department of Anatomy and Embryology, Leiden University Medical Center
Bastiaan T. Heijmans: Molecular Epidemiology Section, Leiden University Medical Center
Susana M. Chuva de Sousa Lopes: Department of Anatomy and Embryology, Leiden University Medical Center

DOI: https://doi.org/10.1038/s41467-017-01077-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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While DNA methylation and gene expression data are widely available for animal models, comprehensive data from human development is rarer. Here, the authors generated transcriptional and DNA methylation data from 21 organs during human development and 6 isogenic induced pluripotent stem cell lines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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