Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening

Kerstin Klinkert; Murielle Rocancourt; Anne Houdusse; Arnaud Echard

doi:10.1038/ncomms11166

Nature Communications (Apr 2016)

Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening

Kerstin Klinkert,
Murielle Rocancourt,
Anne Houdusse,
Arnaud Echard

Affiliations

Kerstin Klinkert: Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur
Murielle Rocancourt: Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur
Anne Houdusse: Institut Curie, Structural Motility Lab
Arnaud Echard: Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur

DOI: https://doi.org/10.1038/ncomms11166
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Establishment and maintenance of apico-basal polarity in epithelial organs needs to be tightly coupled with cell division. Here the authors show that the Rab35 GTPase tethers intracellular vesicles containing key apical determinants at the cleavage site, connecting cytokinesis to apico-basal polarity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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