Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

Shir Filo; Oshrat Shtangel; Noga Salamon; Adi Kol; Batsheva Weisinger; Sagiv Shifman; Aviv A. Mezer

doi:10.1038/s41467-019-11319-1

Nature Communications (Jul 2019)

Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

Shir Filo,
Oshrat Shtangel,
Noga Salamon,
Adi Kol,
Batsheva Weisinger,
Sagiv Shifman,
Aviv A. Mezer

Affiliations

Shir Filo: The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem
Oshrat Shtangel: The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem
Noga Salamon: The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem
Adi Kol: The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem
Batsheva Weisinger: The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem
Sagiv Shifman: Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem
Aviv A. Mezer: The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem

DOI: https://doi.org/10.1038/s41467-019-11319-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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MRI has been used for the non-invasive imaging of human brain aging but is sensitive to both tissue molecular composition and water content. Here the authors present a quantitative MRI method that discriminates these factors and describe region-specific changes in the molecular composition of the aging human brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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