Southern African Journal of HIV Medicine (Sep 2013)

Consensus statement: Management of drug-induced liver injury in HIV-positive patients treated for TB

  • E Jong,
  • F Conradie,
  • R Berhanu,
  • A Black,
  • M-A John,
  • G Meintjes,
  • C Menezes

DOI
https://doi.org/10.4102/sajhivmed.v14i3.63
Journal volume & issue
Vol. 14, no. 3
pp. 113 – 119

Abstract

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Drug-induced liver injury (DILI) in HIV/tuberculosis (TB) co-infected patients is a common problem in the South African setting, and re-introduction of anti-TB drugs can be challenging for the healthcare worker. Although international guidelines on the re-introduction of TB treatment are available, the definition of DILI is not uniform, management of antiretroviral therapy (ART) in HIV co-infection is not mentioned, and the guidance on management is not uniform and lacks a practical approach. In this consensus statement, we summarise important aspects of DILI and provide practical guidance for healthcare workers for different patient groups and healthcare settings on the re-introduction of anti-TB drugs and ART in HIV/TB co-infected individuals presenting with DILI.

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