Nature Communications (Oct 2021)
Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis
- Saurabh J. Pradhan,
- Puli Chandramouli Reddy,
- Michael Smutny,
- Ankita Sharma,
- Keisuke Sako,
- Meghana S. Oak,
- Rini Shah,
- Mrinmoy Pal,
- Ojas Deshpande,
- Greg Dsilva,
- Yin Tang,
- Rakesh Mishra,
- Girish Deshpande,
- Antonio J. Giraldez,
- Mahendra Sonawane,
- Carl-Philipp Heisenberg,
- Sanjeev Galande
Affiliations
- Saurabh J. Pradhan
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- Puli Chandramouli Reddy
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- Michael Smutny
- Institute of Science and Technology Austria
- Ankita Sharma
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- Keisuke Sako
- Institute of Science and Technology Austria
- Meghana S. Oak
- Indian Institute of Science Education and Research
- Rini Shah
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- Mrinmoy Pal
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- Ojas Deshpande
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- Greg Dsilva
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- Yin Tang
- Department of Genetics, Yale University School of Medicine
- Rakesh Mishra
- Centre for Cellular and Molecular Biology
- Girish Deshpande
- Department of Molecular Biology, Princeton University
- Antonio J. Giraldez
- Department of Genetics, Yale University School of Medicine
- Mahendra Sonawane
- Department of Biological Sciences, Tata Institute of Fundamental Research
- Carl-Philipp Heisenberg
- Institute of Science and Technology Austria
- Sanjeev Galande
- Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research
- DOI
- https://doi.org/10.1038/s41467-021-26234-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Activation of the zygotic genome is a critical transition during development, though the link to tissue-specific gene regulation remains unclear. Here the authors demonstrate distinct functions for Satb2 before and after zygotic genome activation, highlighting the temporal coordination of these roles.
