Potential effects of metal ion induced two-state allostery on the regulatory mechanism of add adenine riboswitch

Lei Bao; Wen-Bin Kang; Yi Xiao

doi:10.1038/s42003-022-04096-z

Communications Biology (Oct 2022)

Potential effects of metal ion induced two-state allostery on the regulatory mechanism of add adenine riboswitch

Lei Bao,
Wen-Bin Kang,
Yi Xiao

Affiliations

Lei Bao: School of Public Health, Hubei University of Medicine
Wen-Bin Kang: School of Public Health, Hubei University of Medicine
Yi Xiao: Institute of Biophysics, School of Physics, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s42003-022-04096-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Molecular dynamic simulations are employed to assess the influence of metal ions on riboswitch structure and dynamics, suggesting a conformational control of riboswitch aptamers by metal ions before ligand binding.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal