Research progress of Hippo signaling pathway in diabetic retinopathy

Abstract

Diabetic retinopathy has a serious impact on the quality of life of diabetes patients. In clinic, anti-vascular endothelial growth factor, laser or surgical treatment are mainly used, which has limited therapeutic effect, so it is urgent to update more effective prevention and treatment methods. The Hippo signaling pathway is a complex kinase chain that includes a series of kinases and transcription factors involved in regulating processes such as cell proliferation, differentiation, and apoptosis. It has been proved that there is a typical Hippo signaling pathway in the human retina, and its main influencing factor YAP/TEA regulates the process of retinal endothelium and angiogenesis. This article reviews the composition and regulatory mechanism of Hippo signaling pathway, the relationship between Hippo signaling pathway and other signaling pathways and risk factors in diabetic retinopathy, and related drug treatment, in order to provide a broader idea for the prevention and treatment of diabetic retinopathy.

Keywords

• diabetic retinopathy
• hippo signaling pathway
• yes related protein
• sugar metabolism
• oxidative stress
• angiogenesis
• metformin
• verteporfin
• inflammation