Nature Communications (Nov 2020)
Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial
- Christina Balle,
- Iyaloo N. Konstantinus,
- Shameem Z. Jaumdally,
- Enock Havyarimana,
- Katie Lennard,
- Rachel Esra,
- Shaun L. Barnabas,
- Anna-Ursula Happel,
- Zoe Moodie,
- Katherine Gill,
- Tanya Pidwell,
- Ulas Karaoz,
- Eoin Brodie,
- Venessa Maseko,
- Hoyam Gamieldien,
- Steven E. Bosinger,
- Landon Myer,
- Linda-Gail Bekker,
- Jo-Ann S. Passmore,
- Heather B. Jaspan
Affiliations
- Christina Balle
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Iyaloo N. Konstantinus
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Shameem Z. Jaumdally
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Enock Havyarimana
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Katie Lennard
- Department of Integrative Biomedical Sciences, University of Cape Town
- Rachel Esra
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Shaun L. Barnabas
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Anna-Ursula Happel
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Zoe Moodie
- Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center
- Katherine Gill
- Desmond Tutu HIV Centre, University of Cape Town
- Tanya Pidwell
- Desmond Tutu HIV Centre, University of Cape Town
- Ulas Karaoz
- Earth and Environmental Science, Lawrence Berkeley National Laboratories
- Eoin Brodie
- Earth and Environmental Science, Lawrence Berkeley National Laboratories
- Venessa Maseko
- National Institute for Communicable Diseases, Sandringham
- Hoyam Gamieldien
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Steven E. Bosinger
- Department of Pathology & Laboratory Medicine, Emory University School of Medicine; Division of Microbiology and Immunology, Yerkes National Primate Research Center
- Landon Myer
- Division of Epidemiology, Biostatistics, School of Public Health & Family Medicine, University of Cape Town
- Linda-Gail Bekker
- Desmond Tutu HIV Centre, University of Cape Town
- Jo-Ann S. Passmore
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Heather B. Jaspan
- Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- DOI
- https://doi.org/10.1038/s41467-020-19382-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Hormonal contraception may alter women’s susceptibility to HIV. Here, the authors report the results of a randomized clinical trial substudy assessing the effects of injectable Net-En, oral contraceptives (COC) and Nuvaring on vaginal microbiota and cytokines, associating COC with lower microbial diversity and Nuvaring with increased inflammation.
