Nature Communications (Oct 2017)
NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
- Melanie Märklin,
- Jonas S. Heitmann,
- Alexander R. Fuchs,
- Felicia M. Truckenmüller,
- Michael Gutknecht,
- Stefanie Bugl,
- Sebastian J. Saur,
- Juliane Lazarus,
- Ursula Kohlhofer,
- Leticia Quintanilla-Martinez,
- Hans-Georg Rammensee,
- Helmut R. Salih,
- Hans-Georg Kopp,
- Michael Haap,
- Andreas Kirschniak,
- Lothar Kanz,
- Anjana Rao,
- Stefan Wirths,
- Martin R. Müller
Affiliations
- Melanie Märklin
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Jonas S. Heitmann
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Alexander R. Fuchs
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Felicia M. Truckenmüller
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Michael Gutknecht
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Stefanie Bugl
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Sebastian J. Saur
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Juliane Lazarus
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Ursula Kohlhofer
- Department of Pathology, University of Tübingen
- Leticia Quintanilla-Martinez
- Department of Pathology, University of Tübingen
- Hans-Georg Rammensee
- Department of Immunology, University of Tübingen
- Helmut R. Salih
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Hans-Georg Kopp
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Michael Haap
- Department of Endocrinology, Diabetology, Clinical Pathology and Metabolism, University of Tübingen
- Andreas Kirschniak
- Department of Surgery, University of Tübingen
- Lothar Kanz
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Anjana Rao
- La Jolla Institute of Allergy and Immunology
- Stefan Wirths
- Department of Oncology, Haematology and Immunology, University of Tübingen
- Martin R. Müller
- Department of Oncology, Haematology and Immunology, University of Tübingen
- DOI
- https://doi.org/10.1038/s41467-017-00830-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
NFAT2 is a transcription factor that has been linked with chronic lymphocytic leukaemia (CLL), but its functions in CLL manifestation are still unclear. Here the authors show, by analysing mouse CLL models and characterising biopsies from CLL patients, that NFAT2 is an important regulator for the anergic phenotype of CLL.
