Synthetic Applications of Aziridinium Ions

Abstract

Nonactivated aziridine with an electron-donating group at the ring nitrogen should be activated to an aziridinium ion prior to being converted to cyclic and acyclic nitrogen-containing molecules. This review describes ways to generate aziridinium ions and their utilization for synthetic purposes. Specifically, the intra- and intermolecular formation of aziridinium ions with proper electrophiles are classified, and their regio- and stereoselective transformations with nucleophiles are described on the basis of recent developments.

Keywords

• aziridine
• nonactivated aziridine
• aziridinium ion
• ring-opening
• synthesis
• nitrogen-containing molecules