Frontiers in Cell and Developmental Biology (Apr 2021)
Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer
- Longchang Bai,
- Longchang Bai,
- Longchang Bai,
- Yingkang Ma,
- Yingkang Ma,
- Yingkang Ma,
- Xue Wang,
- Qiongni Feng,
- Qiongni Feng,
- Zhining Zhang,
- Zhining Zhang,
- Zhining Zhang,
- Sijie Wang,
- Sijie Wang,
- Sijie Wang,
- Huijie Zhang,
- Huijie Zhang,
- Huijie Zhang,
- Xinyu Lu,
- Xinyu Lu,
- Xinyu Lu,
- Yonghui Xu,
- Erhu Zhao,
- Erhu Zhao,
- Erhu Zhao,
- Hongjuan Cui,
- Hongjuan Cui,
- Hongjuan Cui,
- Hongjuan Cui
Affiliations
- Longchang Bai
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Longchang Bai
- Westa College, Southwest University, Chongqing, China
- Longchang Bai
- Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, China
- Yingkang Ma
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Yingkang Ma
- Westa College, Southwest University, Chongqing, China
- Yingkang Ma
- Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, China
- Xue Wang
- Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China
- Qiongni Feng
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Qiongni Feng
- Westa College, Southwest University, Chongqing, China
- Zhining Zhang
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Zhining Zhang
- Westa College, Southwest University, Chongqing, China
- Zhining Zhang
- Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, China
- Sijie Wang
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Sijie Wang
- Westa College, Southwest University, Chongqing, China
- Sijie Wang
- Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, China
- Huijie Zhang
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Huijie Zhang
- Westa College, Southwest University, Chongqing, China
- Huijie Zhang
- Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, China
- Xinyu Lu
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Xinyu Lu
- Westa College, Southwest University, Chongqing, China
- Xinyu Lu
- Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, China
- Yonghui Xu
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Erhu Zhao
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Erhu Zhao
- Cancer Center, Medical Research Institute, Southwest University, Chongqing, China
- Erhu Zhao
- Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing, China
- Hongjuan Cui
- State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China
- Hongjuan Cui
- Cancer Center, Medical Research Institute, Southwest University, Chongqing, China
- Hongjuan Cui
- Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, China
- Hongjuan Cui
- Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing, China
- DOI
- https://doi.org/10.3389/fcell.2021.587218
- Journal volume & issue
-
Vol. 9
Abstract
Polydatin, an active ingredient from the roots of Polygonum cuspidatum, is considered to have protective effects on the cardiovascular system and liver. In this study, we demonstrated that polydatin has antitumor activity against human cervical cancer. Polydatin efficiently inhibited cervical cancer cell proliferation by regulating cell cycle-related proteins including p21, p27, CDK2, CDK4, Cyclin D1, and Cyclin E1. Furthermore, polydatin suppressed cell invasion and migration by regulating epithelial–mesenchymal transition (EMT) markers, including E-cadherin, N-cadherin, Snail and Slug. The c-Myc, as a proto-oncogene, is considered to be closely associated with the proliferation and metastasis of tumor cells. After polydatin treatment, the protein expression of c-Myc showed a significant decrease. Based on these data, we overexpressed c-Myc in cervical cancer cells and observed that the overexpression of c-Myc rescued the inhibitory effect of polydatin on cell proliferation and metastasis. These results indicated that polydatin can inhibit cell proliferation and metastasis through suppressing the c-Myc expression in human cervical cancer.
Keywords
