EBioMedicine (Jun 2017)

Reduced Intellectual Ability in Offspring of Ovarian Hyperstimulation Syndrome: A Cohort Study

  • Gu-Feng Xu,
  • Cheng-Liang Zhou,
  • Yi-Meng Xiong,
  • Jing-Yi Li,
  • Tian-Tian Yu,
  • Shen Tian,
  • Xian-Hua Lin,
  • Yun Liao,
  • Yuan Lv,
  • Fang-Hong Zhang,
  • Zhi-Wei Liu,
  • Yin-Yin Shi,
  • Yan Shen,
  • Jin Sha,
  • Dan Zhang,
  • Yi-Min Zhu,
  • Jian-Zhong Sheng,
  • He-Feng Huang

DOI
https://doi.org/10.1016/j.ebiom.2017.05.020
Journal volume & issue
Vol. 20, no. C
pp. 263 – 267

Abstract

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Background: Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. Methods: We recruited 86 Chinese children born to OHSS women and 172 children conceived with non-OHSS In Vitro Fertilization (IVF) in this cohort study. Their intellectual ability was assessed according to the Revised Chinese Version of the Wechsler Intelligence Scale for Children (C-WISC). Verbal Intelligence Quotient (VIQ), Performance Intelligence Quotient (PIQ), and Full Intelligence Quotient (FIQ) were calculated. The investigation was registered in Chinese Clinical Trial Registry (ChiCTR-SOC-16009555). Findings: OHSS offspring scored less on C-WISC (mean (standard deviation [SD]): (VIQ = 92.7 (14.7), PIQ = 108.9 (13.1), FIQ = 100.6 (13.4)) compared with non-OHSS IVF offspring (VIQ = 100.1 (13.2), PIQ = 113.7 (10.8), FIQ = 107.4 (11.5)). The prevalence of low IQ (<80) children was 4.7 times higher in OHSS offspring compared with non-OHSS offspring. Maternal estradiol level on hCG administration day was negatively associated with FIQ in offspring. Interpretation: OHSS offspring displayed reduced intellectual ability. Prenatal estradiol exposure might be involved in underlying mechanism.

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