Nature Communications (Dec 2020)
Cerebral small vessel disease genomics and its implications across the lifespan
- Muralidharan Sargurupremraj,
- Hideaki Suzuki,
- Xueqiu Jian,
- Chloé Sarnowski,
- Tavia E. Evans,
- Joshua C. Bis,
- Gudny Eiriksdottir,
- Saori Sakaue,
- Natalie Terzikhan,
- Mohamad Habes,
- Wei Zhao,
- Nicola J. Armstrong,
- Edith Hofer,
- Lisa R. Yanek,
- Saskia P. Hagenaars,
- Rajan B. Kumar,
- Erik B. van den Akker,
- Rebekah E. McWhirter,
- Stella Trompet,
- Aniket Mishra,
- Yasaman Saba,
- Claudia L. Satizabal,
- Gregory Beaudet,
- Laurent Petit,
- Ami Tsuchida,
- Laure Zago,
- Sabrina Schilling,
- Sigurdur Sigurdsson,
- Rebecca F. Gottesman,
- Cora E. Lewis,
- Neelum T. Aggarwal,
- Oscar L. Lopez,
- Jennifer A. Smith,
- Maria C. Valdés Hernández,
- Jeroen van der Grond,
- Margaret J. Wright,
- Maria J. Knol,
- Marcus Dörr,
- Russell J. Thomson,
- Constance Bordes,
- Quentin Le Grand,
- Marie-Gabrielle Duperron,
- Albert V. Smith,
- David S. Knopman,
- Pamela J. Schreiner,
- Denis A. Evans,
- Jerome I. Rotter,
- Alexa S. Beiser,
- Susana Muñoz Maniega,
- Marian Beekman,
- Julian Trollor,
- David J. Stott,
- Meike W. Vernooij,
- Katharina Wittfeld,
- Wiro J. Niessen,
- Aicha Soumaré,
- Eric Boerwinkle,
- Stephen Sidney,
- Stephen T. Turner,
- Gail Davies,
- Anbupalam Thalamuthu,
- Uwe Völker,
- Mark A. van Buchem,
- R. Nick Bryan,
- Josée Dupuis,
- Mark E. Bastin,
- David Ames,
- Alexander Teumer,
- Philippe Amouyel,
- John B. Kwok,
- Robin Bülow,
- Ian J. Deary,
- Peter R. Schofield,
- Henry Brodaty,
- Jiyang Jiang,
- Yasuharu Tabara,
- Kazuya Setoh,
- Susumu Miyamoto,
- Kazumichi Yoshida,
- Manabu Nagata,
- Yoichiro Kamatani,
- Fumihiko Matsuda,
- Bruce M. Psaty,
- David A. Bennett,
- Philip L. De Jager,
- Thomas H. Mosley,
- Perminder S. Sachdev,
- Reinhold Schmidt,
- Helen R. Warren,
- Evangelos Evangelou,
- David-Alexandre Trégouët,
- International Network against Thrombosis (INVENT) Consortium,
- International Headache Genomics Consortium (IHGC),
- Mohammad A. Ikram,
- Wei Wen,
- Charles DeCarli,
- Velandai K. Srikanth,
- J. Wouter Jukema,
- Eline P. Slagboom,
- Sharon L. R. Kardia,
- Yukinori Okada,
- Bernard Mazoyer,
- Joanna M. Wardlaw,
- Paul A. Nyquist,
- Karen A. Mather,
- Hans J. Grabe,
- Helena Schmidt,
- Cornelia M. Van Duijn,
- Vilmundur Gudnason,
- William T. Longstreth,
- Lenore J. Launer,
- Mark Lathrop,
- Sudha Seshadri,
- Christophe Tzourio,
- Hieab H. Adams,
- Paul M. Matthews,
- Myriam Fornage,
- Stéphanie Debette
Affiliations
- Muralidharan Sargurupremraj
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Hideaki Suzuki
- Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryo, Aoba
- Xueqiu Jian
- University of Texas Health Science Center at Houston McGovern Medical School
- Chloé Sarnowski
- Department of Biostatistics, Boston University School of Public Health
- Tavia E. Evans
- Department of Clinical Genetics, Erasmus MC
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Gudny Eiriksdottir
- Icelandic Heart Association
- Saori Sakaue
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Natalie Terzikhan
- Department of Epidemiology, Erasmus MC
- Mohamad Habes
- Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- Nicola J. Armstrong
- Mathematics and Statistics, Murdoch University
- Edith Hofer
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Lisa R. Yanek
- GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine
- Saskia P. Hagenaars
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Rajan B. Kumar
- Department of Public Health Sciences, University of California at Davis
- Erik B. van den Akker
- Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center
- Rebekah E. McWhirter
- Centre for Law and Genetics, Faculty of Law, University of Tasmania
- Stella Trompet
- Department of Internal Medicine, section of gerontology and geriatrics, Leiden University Medical Center
- Aniket Mishra
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Yasaman Saba
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Claudia L. Satizabal
- Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center
- Gregory Beaudet
- University of Bordeaux, IMN
- Laurent Petit
- University of Bordeaux, IMN
- Ami Tsuchida
- University of Bordeaux, IMN
- Laure Zago
- University of Bordeaux, IMN
- Sabrina Schilling
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Sigurdur Sigurdsson
- Icelandic Heart Association
- Rebecca F. Gottesman
- Johns Hopkins University School of Medicine
- Cora E. Lewis
- University of Alabama at Birmingham School of Medicine
- Neelum T. Aggarwal
- Department of Neurological Sciences, Rush University Medical Center
- Oscar L. Lopez
- Departments of Neurology and Psychiatry, University of Pittsburgh
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Maria C. Valdés Hernández
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Jeroen van der Grond
- Department of Radiology, Leiden University medical Center
- Margaret J. Wright
- Queensland Brain Institute, The University of Queensland
- Maria J. Knol
- Department of Epidemiology, Erasmus MC
- Marcus Dörr
- Department of Internal Medicine B, University Medicine Greifswald
- Russell J. Thomson
- Menzies Institute for Medical Research, University of Tasmania
- Constance Bordes
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Quentin Le Grand
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Marie-Gabrielle Duperron
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Albert V. Smith
- Icelandic Heart Association
- David S. Knopman
- Mayo Clinic
- Pamela J. Schreiner
- University of Minnesota School of Public Health
- Denis A. Evans
- Department of Internal Medicine, Rush University Medical Center
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
- Alexa S. Beiser
- Department of Biostatistics, Boston University School of Public Health
- Susana Muñoz Maniega
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Marian Beekman
- Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center
- Julian Trollor
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- David J. Stott
- Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Meike W. Vernooij
- Department of Radiology & Nuclear Medicine, Erasmus MC
- Katharina Wittfeld
- German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald
- Wiro J. Niessen
- Department of Radiology & Nuclear Medicine, Erasmus MC
- Aicha Soumaré
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Eric Boerwinkle
- University of Texas Health Science Center at Houston School of Public Health
- Stephen Sidney
- Kaiser Permanente Division of Research
- Stephen T. Turner
- Division of Nephrology and Hypertension, Mayo Clinic
- Gail Davies
- Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz
- Anbupalam Thalamuthu
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
- Uwe Völker
- Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
- Mark A. van Buchem
- Row Fogo Centre for Ageing and The Brain, University of Edinburgh
- R. Nick Bryan
- The University of Texas at Austin Dell Medical School
- Josée Dupuis
- Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center
- Mark E. Bastin
- Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz
- David Ames
- National Ageing Research Institute Royal Melbourne Hospital
- Alexander Teumer
- Department of Epidemiology, Erasmus MC
- Philippe Amouyel
- Inserm U1167
- John B. Kwok
- Brain and Mind Centre - The University of Sydney
- Robin Bülow
- Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald
- Ian J. Deary
- Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz
- Peter R. Schofield
- School of Medical Sciences, University of New South Wales
- Henry Brodaty
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
- Jiyang Jiang
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
- Yasuharu Tabara
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Kazuya Setoh
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
- Susumu Miyamoto
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
- Kazumichi Yoshida
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
- Manabu Nagata
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
- Yoichiro Kamatani
- Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku
- Fumihiko Matsuda
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Bruce M. Psaty
- Departments of Epidemiology, Medicine and Health Services, University of Washington
- David A. Bennett
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Philip L. De Jager
- Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Thomas H. Mosley
- Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center
- Perminder S. Sachdev
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
- Reinhold Schmidt
- Department of Epidemiology, School of Public Health, University of Michigan
- Helen R. Warren
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Evangelos Evangelou
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- David-Alexandre Trégouët
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- International Network against Thrombosis (INVENT) Consortium
- International Headache Genomics Consortium (IHGC)
- Mohammad A. Ikram
- Department of Epidemiology, Erasmus MC
- Wei Wen
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Charles DeCarli
- Department of Neurology and Center for Neuroscience, University of California at Davis
- Velandai K. Srikanth
- Menzies Institute for Medical Research, University of Tasmania
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Eline P. Slagboom
- Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Yukinori Okada
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Bernard Mazoyer
- University of Bordeaux, IMN
- Joanna M. Wardlaw
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Paul A. Nyquist
- Department of Neurology, Johns Hopkins School of Medicine
- Karen A. Mather
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Hans J. Grabe
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Helena Schmidt
- Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz
- Cornelia M. Van Duijn
- Nuffield Department of Population Health, University of Oxford
- Vilmundur Gudnason
- Icelandic Heart Association
- William T. Longstreth
- Departments of Neurology and Epidemiology, University of Washington
- Lenore J. Launer
- Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health
- Mark Lathrop
- University of McGill Genome Center
- Sudha Seshadri
- Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center
- Christophe Tzourio
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- Hieab H. Adams
- Department of Clinical Genetics, Erasmus MC
- Paul M. Matthews
- Department of Brain Sciences, Imperial College London
- Myriam Fornage
- University of Texas Health Science Center at Houston McGovern Medical School
- Stéphanie Debette
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center
- DOI
- https://doi.org/10.1038/s41467-020-19111-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.
