Nature Communications (Apr 2018)

Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

  • Hai Zemmour,
  • David Planer,
  • Judith Magenheim,
  • Joshua Moss,
  • Daniel Neiman,
  • Dan Gilon,
  • Amit Korach,
  • Benjamin Glaser,
  • Ruth Shemer,
  • Giora Landesberg,
  • Yuval Dor

DOI
https://doi.org/10.1038/s41467-018-03961-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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The detection of cardiomyocyte death is a critical aspect in the diagnosis and monitoring of heart diseases. Here the authors show that cardiomyocyte-specific methylation patterns of circulating cell-free DNA may serve as a biomarker of cardiac cell death in infarcted and septic patients.