Nature Communications (Mar 2021)
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia
- Ganqian Zhu,
- Huacheng Luo,
- Yang Feng,
- Olga A. Guryanova,
- Jianfeng Xu,
- Shi Chen,
- Qian Lai,
- Arati Sharma,
- Bing Xu,
- Zhigang Zhao,
- Ru Feng,
- Hongyu Ni,
- David Claxton,
- Ying Guo,
- Ruben A. Mesa,
- Yi Qiu,
- Feng-Chun Yang,
- Wei Li,
- Stephen D. Nimer,
- Suming Huang,
- Mingjiang Xu
Affiliations
- Ganqian Zhu
- Department of Molecular Medicine, University of Texas Health San Antonio
- Huacheng Luo
- Department of Pediatrics, Pennsylvania State University College of Medicine
- Yang Feng
- Department of Pharmacology and Therapeutics, University of Florida College of Medicine
- Olga A. Guryanova
- Department of Pharmacology and Therapeutics, University of Florida College of Medicine
- Jianfeng Xu
- Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine
- Shi Chen
- Department of Molecular Medicine, University of Texas Health San Antonio
- Qian Lai
- Department of Pediatrics, Pennsylvania State University College of Medicine
- Arati Sharma
- Division of Hematology/Oncology, Department of Medicine, Pennsylvania State University College of Medicine
- Bing Xu
- Department of Hematology, The First Affiliated Hospital of Xiamen University
- Zhigang Zhao
- Department of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy
- Ru Feng
- Department of Hematology, Nanfang Hospital, Southern Medical University
- Hongyu Ni
- Department of Pathology, Wayne State University School of Medicine
- David Claxton
- Division of Hematology/Oncology, Department of Medicine, Pennsylvania State University College of Medicine
- Ying Guo
- Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine
- Ruben A. Mesa
- Department of Medicine, University of Texas Health San Antonio
- Yi Qiu
- Penn State Cancer Institute, Pennsylvania State University College of Medicine
- Feng-Chun Yang
- Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine
- Wei Li
- Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California
- Stephen D. Nimer
- Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Suming Huang
- Department of Pediatrics, Pennsylvania State University College of Medicine
- Mingjiang Xu
- Department of Molecular Medicine, University of Texas Health San Antonio
- DOI
- https://doi.org/10.1038/s41467-021-22095-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Nucleophosmin (NPM1) gene mutation induces a specific gene expression program leading to acute myeloid leukaemia. Here, the authors show that mutant NPM1 activates a HOXB locus-associated long non-coding RNA which is essential for its associated oncogenic transcriptional program and leukaemia development.
