The application of CRISPR-Cas system in Staphylococcus aureus infection
Jiamin Wang,
Fang Liu,
Jinzhao Long,
Yuefei Jin,
Shuaiyin Chen,
Guangcai Duan,
Haiyan Yang
Affiliations
Jiamin Wang
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Fang Liu
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Jinzhao Long
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Yuefei Jin
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Shuaiyin Chen
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Guangcai Duan
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Haiyan Yang
Corresponding author.Department of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou 450001, China; Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated nuclease (Cas) system has been proven to play an irreplaceable role in bacteria immunity activity against exogenous genetic elements. In recent years, this system has emerged as a valid gene engineering method and could be used to detect and treat various microorganisms such as bacteria and viruses, etc. Staphylococcus aureus, as a Gram-positive, opportunistic human and animal pathogen, can cause a variety of diseases greatly threatening human health. Here, we mainly reviewed the applications of the CRISPR-Cas system in Staphylococcus aureus infections in detail. Furthermore, the prospects and drawbacks of the CRISPR-Cas system were also discussed.
