Evaluation of the toxicity of glucocorticoids in patients with autoimmune blistering disease using the Glucocorticoid Toxicity Index: A cohort studyCapsule Summary

Yicong Liang, MD; Faith A.P. Zeng; Tabrez Sheriff, MD; Anna Wilson, MD; Asli Bilgic, MD; Grant Feng; John H. Stone, MD, MPH; Dedee F. Murrell, MA, BMBCh, MD

JAAD International (Mar 2022)

Evaluation of the toxicity of glucocorticoids in patients with autoimmune blistering disease using the Glucocorticoid Toxicity Index: A cohort studyCapsule Summary

Yicong Liang, MD,
Faith A.P. Zeng,
Tabrez Sheriff, MD,
Anna Wilson, MD,
Asli Bilgic, MD,
Grant Feng,
John H. Stone, MD, MPH,
Dedee F. Murrell, MA, BMBCh, MD

Affiliations

Yicong Liang, MD: Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Faith A.P. Zeng: Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Tabrez Sheriff, MD: Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Anna Wilson, MD: Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Asli Bilgic, MD: Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia; Department of Dermatology, Akdeniz University, Antalya, Turkey
Grant Feng: Data Science, WooliesX, Sydney, New South Wales, Australia
John H. Stone, MD, MPH: Department of Rheumatology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts
Dedee F. Murrell, MA, BMBCh, MD: Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia; Correspondence to: Dedee F. Murrell, MA, BMBCh, MD, Department of Dermatology, Ground Floor, James Laws House, St George Hospital, Gray St, Kogarah, NSW 2217, Australia.

Journal volume & issue: Vol. 6
pp. 68 – 76

Abstract

Read online

Background: Glucocorticoids are the mainstay of treatment for autoimmune blistering diseases (AIBDs). The Glucocorticoid Toxicity Index (GTI) is a novel, outcome-based glucocorticoid-induced adverse effects monitoring instrument. Objective: To investigate whether the GTI score was able to accurately quantify the glucocorticoid-induced toxicity in patients with AIBDs. Methods: The prospective cohort study included patients with confirmed diagnoses of AIBDs (group1, currently receiving glucocorticoids; and group 2, had glucocorticoids ceased earlier). Data were collected minimally at baseline (V1) and 3 months (V2). Further data from patients who were able to complete the follow-up visits at 6 months (V3) and 12 months (V4) amid the COVID-19 pandemic were also included. GTI scores were calculated after data collection. Results: Analysis of data from V1 and V2 found a linear correlation between GTI score and prednisone doses (P < .05) and a significant difference in GTI scores between group1 and group 2 (P < .05). Data from V3 and V4 suggested that GTI scores continued to rise progressively alongside increasing cumulative prednisone dose. Limitations: Small sample size, further exacerbated by the COVID-19 pandemic. Single-center study. Conclusion: The GTI sensitively and specifically captured the changes in glucocorticoids toxicity over time among patients with AIBDs. The GTI could be a feasible tool that can be used in future clinical trials as a glucocorticoid-induced toxicity outcome measure.

Published in JAAD International

ISSN: 2666-3287 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Dermatology
Website: https://www.journals.elsevier.com/jaad-international

About the journal

Abstract

Keywords