Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties

Masaki Takasugi; Denis Firsanov; Gregory Tombline; Hanbing Ning; Julia Ablaeva; Andrei Seluanov; Vera Gorbunova

doi:10.1038/s41467-020-16050-w

Nature Communications (May 2020)

Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties

Masaki Takasugi,
Denis Firsanov,
Gregory Tombline,
Hanbing Ning,
Julia Ablaeva,
Andrei Seluanov,
Vera Gorbunova

Affiliations

Masaki Takasugi: Department of Biology, University of Rochester
Denis Firsanov: Department of Biology, University of Rochester
Gregory Tombline: Department of Biology, University of Rochester
Hanbing Ning: Department of Digestive Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Julia Ablaeva: Department of Biology, University of Rochester
Andrei Seluanov: Department of Biology, University of Rochester
Vera Gorbunova: Department of Biology, University of Rochester

DOI: https://doi.org/10.1038/s41467-020-16050-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by these species.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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