Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A

Abstract

Shubhra Chaturvedi,1 Sangeeta Lal,2 Prasenjit Sen,3 Anil K Mishra1 1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, New Delhi, Delhi, 2Department of Physics, B.S. College, Magadh University, Patna, Bihar, 3School of Physical Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India Abstract: Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT1A receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities. Keywords: receptor imaging, optical imaging, targeted nanoparticles

Keywords

• Receptor Imaging
• Optical Imaging
• Targeted Nanoparticles.