Synthesis, spectroscopic characterization and DNA binding studies of Cu(II) complex of Schiff base containing benzothiazole moiety

Abstract

A Schiff base ligand L has been synthesized by the condensation of thiophene-2-carbaldehyde and 2-amino-6-methylbenzothiazole. It has been characterized by elemental analysis, Infrared (IR), 1H NMR and mass spectrometry. Copper (II) complex, ML2 has been synthesized by the reacting ligand L and Copper (II) acetate in 2:1 molar ratio. The Cu(II) complex was characterized by elemental analysis, molar conductance, electronic spectrum, IR and electronic paramagnetic resonance spectrum. TGA has been done to check the thermal stablity of Cu(II) complex. Spectroscopic studies revealed that ligand L binds with the Cu(II) ion as bidentate fashion. On the basis of spectral studies, a distored octahedral geometry has been assigned for Cu(II) complexof ligand L. The DNA binding studies of Cu(II) complex ML2 have been investigated by UV-vis absorption and fluorescence spectroscopy. The binding mode of ML2 with CT-DNA could be assigned as intercalation of the metal complex between DNA base pairs.

Keywords

• schiff base
• cu(ii) complex
• tga
• ct-dna binding