Time course of changes in bone resorption markers during pamidronate therapy in breast cancer patients with bone metastases

Abstract

The paper gives the results of evaluating the time course of changes in the level of bone resorption markers (S-CTx and dPir) in pami- dronate-treated patients with bone metastases from breast cancer. It shows the relationship of these markers to clinical and X-ray find- ings. The markers were not found to be of high clinical significance as a means for diagnosing bone metastases and estimating treat- ment trends.

Keywords

• breast cancer
• bone metastases
• bone resorption markers