Nature Communications (Jan 2020)

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

  • Nicolai Franzmeier,
  • Julia Neitzel,
  • Anna Rubinski,
  • Ruben Smith,
  • Olof Strandberg,
  • Rik Ossenkoppele,
  • Oskar Hansson,
  • Michael Ewers,
  • Alzheimer’s Disease Neuroimaging Initiative (ADNI)

DOI
https://doi.org/10.1038/s41467-019-14159-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Tau accumulation is associated with disease progression in Alzheimer’s disease. Here the authors use resting state fMRI and tau-PET to demonstrate that baseline connectivity in Alzheimer's disease is associated with tau spreading.