Glucose promotes cell growth by suppressing branched-chain amino acid degradation

Dan Shao; Outi Villet; Zhen Zhang; Sung Won Choi; Jie Yan; Julia Ritterhoff; Haiwei Gu; Danijel Djukovic; Danos Christodoulou; Stephen C. Kolwicz; Daniel Raftery; Rong Tian

doi:10.1038/s41467-018-05362-7

Nature Communications (Jul 2018)

Glucose promotes cell growth by suppressing branched-chain amino acid degradation

Dan Shao,
Outi Villet,
Zhen Zhang,
Sung Won Choi,
Jie Yan,
Julia Ritterhoff,
Haiwei Gu,
Danijel Djukovic,
Danos Christodoulou,
Stephen C. Kolwicz,
Daniel Raftery,
Rong Tian

Affiliations

Dan Shao: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Outi Villet: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Zhen Zhang: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Sung Won Choi: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Jie Yan: Department of Medicine, NMR Laboratory of Physiological Chemistry, Brigham and Women’s Hospital
Julia Ritterhoff: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Haiwei Gu: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Danijel Djukovic: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Danos Christodoulou: Department of Medicine, NMR Laboratory of Physiological Chemistry, Brigham and Women’s Hospital
Stephen C. Kolwicz: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Daniel Raftery: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington
Rong Tian: Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington

DOI: https://doi.org/10.1038/s41467-018-05362-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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